Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active growth hormone secretagogue. mimicking the GH stimulating action of the endogenous hormone ghrelin.It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. Legal status in US: Unscheduled originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, mk677 could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis
Benefits
In a study on it’s effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of mk-677 per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Other possible benefits of mk677 are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by (Mk-677), meaning it boosts the immune system to a degree.
In a multitude of studies, (Mk-677) increased IGF-1 levels by between 39-89%. To give you an idea of what IGF-1 does, here are some IGF-1 benefits:
Increased Fat Oxidation (fat loss).
Increased Muscle gains (lean mass).
Tightening up loose skin.
Healing old injuries.
Healing Bones, Tendons and Ligaments.
Side Effects
Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677.
Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you’re prone to prolactin sides? If you get gynecomastia from taking trenbolone, you’re prone to prolactin sides.
Medical
(Mk-677) was found to be very safe and, in fact, showed to reduce tumors in mice, which was hypothesized to be from an increased immune system response.
Also Deer Antler Extract IGF-1
New Zealand Red Deer Antler Velvet
a unique, natural, source of IGF-1
Velvet deer antler is one of the most fascinating medicinal products, and one of the great wonders in nature. Chinese medicine scholars consider it the most important traditional healing remedy next to ginseng. Vegans use it, as well as non-vegans, as a supplement. velvet deer antler has a long history of safe and effective use, as well as decades of scientific research.
The role of the IGF-1 produced naturally in your body is to:
Maintain elasticity in your skin and ligaments
Maintain healthy blood pressure
Support your immune system
Help in healing and recovery
Maintain joint mobility.
Supports Healthy libido.
Support cognitive ability. Nootropics
Ibutamoren
MK-677
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